4-nonylphenol branched ethoxylated

In Japan in three human milk samples provided by different volunteers BPA was analysed and detected in two samples at low concentrations of 0.65 and 0.70 ng/g (Otaka et al., 2003). APs can bind to ER and induce vitellogenin gene expression in animals due to their estrogenic activity [82]. According Li, Jin, and Snyder (2018), the analysis of nonylphenols (NPs) and their precursors NP ethoxylates (NPEOs) (Fig. In stromal cells, ER was expressed from PND 6 in both groups without any PCNA positive cells, but significantly lower values were noted in the OP-treated group up to PND 10. In the environment, NP originates from degradation of nonylphenol ethoxylates, and the principal source is treated wastewater effluent [3,4]. In in vitro and in vivo testicular cancer cell proliferation assay, the nanomolar range of a realistic mixture of 4-tertiary-OP (4-tert-OP) and 4-NP, which corresponds to environmental doses, promoted a maximum proliferation increase of seminoma-derived (TCam-2) and embryonal carcinoma (NT2/D1) cell lines, via CREB-phosphorylation through a rapid, ER36-PI3 kinase nongenomic pathway [75]. OP-treatment, however, delayed and inhibited gland-formation and suppressed ER expression in the invaginated-luminal and glandular epithelium at this time. Since 1975, Dr. Ehrenstorfer has led the way in producing pesticide reference standards. Track the controlled substances in your products and identify the non-conformances. '-' : entry.product.biosafetyLevel}} Tariff Code: {{entry.product.euTariffCode}}. This lowest observed effect concentration was approximately twice as high as the maximum ambient aquatic concentration of 0.69g/L (sum of 4-nonylphenol branched isomers) detected in the Water Quality Survey of Public Water Bodies. 7.5) in food and environment is an increasing concern from the viewpoint of risk assessment due to their endocrine-disrupting effects. Prolonged contact with skin causes irritation. This means that the chosen route for the creation of the dossier is not set in stone. In MCF-7 breast cancer cells, TGF--mediated transcriptional activity was inhibited by estrogen [86]. Please note, shipping and tax are calculated on the checkout page. EcoMundo is a specialist in chemical substances, their action on human health and the environment as well as the international regulations that govern chemical risk (REACH Regulation, CLP, Cosmetics and OTCs, Biocides, Food, etc.). <> }: vs5< u|&"p9Yxv~8FZ)$n?vxFjNtP.QN;Ixq\&erO;q}N}2:2wrR)w]J|MvW\_p~:j*i !ZeysK*2 ?P`&sg'\z]uyj2/}V}%wVr=6?gk u.{M'WRh^o')t:~yU9vU+6(41KH&)SENObm2\X3SVd3` entry.product.displayPartCode : entry.product.code}}, Biosafety Level Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that they fully comply with all applicable biosafety and biomaterial regulations in their country. Christopher J. Kennedy, Lesley K. Shelley, in Fish Physiology, 2013. absorbent Supporting your analysis for over 40 years. Among the most researched surfactants and PCPs, nonylphenol is the only substance currently regulated in Europe by the Priority Substances Directive, stipulating a maximum allowable concentration of 2.0gL1 for inland surface waters (European Union, 2013). Figure 1.5. Endocrine disruption characteristics are the primary cause of concern relating to nonylphenol (Kennedy et al., 2013; European Union, 2020). Yolk-sac Atlantic salmon fry exposed to waterborne E2 (2g/L) or NP (10g/L) for 21 days and raised for one year in clean freshwater experienced higher mortality than unexposed fish during grow-out in freshwater (Lerner et al., 2007). BPA might be of specific interest because low protein binding might favour estrogen-receptor availability (Nagel et al., 1998). 10 things to know about cosmetics regulation in the U.S. Explore our cancer models, research chemicals and reference materials. ;U[.Q6RmumP* e=A_RUIY-2;GeV7nUk].eIV^}V`` En!A!PvVi ?7#b *`oj^*/2YGReu64}?2|d"/_"Y ?UQ!6Ne7t(t0S'skvi+oBF1~H]UVUZwP^^F=>O 3" NP and OP bind to ER and induce ER-dependent gene transcription through ERE promoter in yeast and mammalian cells [83]. {PF~&>oKAF}NKAN#Nu>'l pJ:_*R7(kLfO*%xGGl'.6vX{`* %34E|c\]=' { w}_V"F/{TeHt-i@QN`IFNc&=| yj6ZB.T'F|cP}f8:42 o~t%L jX81db}QNnOZr<6}C:"z0p4R Solve this simple math problem and enter the result. . Slvio VazJr., in Analysis of Chemical Residues in Agriculture, 2021. These results indicate that ER expression in these sites is strongly linked with cell proliferating activity. Use absorbent paper dampened with water to pick up any remaining material. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. They showed that NP induced cell proliferation and progesterone receptor gene expression in MCF-7 cells, and activated cell proliferation in ovariectomized rat endometrium [1]. Contact with eyes causes irritation. Elle peut ventuellement tre utilise pour vous apporter une rponse personnalise. Receive the latest regulatory news and expert advice once a month! Current approaches in sample preparation for trace analysis of selected endocrine-disrupting compounds: Focus on polychlorinated biphenyls, alkylphenols, and parabens. In this study, OP-treatment (sc injections of 100mg/kg, every other day from postnatal days 1 to 15) induced an early and enhanced ER expression in the luminal epithelium compared with age-matched controls from postnatal day (PND) 10 and increased proliferating cell nuclear antigen (PCNA) positive cells up to PND 21. Pack size is required for your order or quote. Therefore, they are sometimes being detected in relatively higher concentrations in human and environmental samples. Several studies previously reported that estrogen/ERs signaling can regulate TGF-/Smad signaling in the following manner. Gas and liquid chromatography coupled to mass spectrometers are still predominant technologies for analysis of the targets, but the supercritical fluid chromatography coupled to tandem mass spectrometer that has emerged recently may become an alternative method. From: Analysis of Chemical Residues in Agriculture, 2021, S.T. Alan L. Blankenship, Katie Coady, in Encyclopedia of Toxicology (Second Edition), 2005. The miniaturized and automated sample preparation techniques, as exemplified by magnetic solid-phase extraction (SPE) and liquid phase microextraction (SPME) have become the promising technologies for analysis of organic residues (Fig. Recently, an in vitro study has shown that alkylphenol compounds, such as OP and NP, are very potent estrogenic agents, and the binding affinity ERs to OP is approximately 1000-fold less than that of estrogen [79]. 3 0 obj 4-nonylphenol is an estrogenic endocrine active chemical that is a derivative from ethoxylated alkylphenol, a non-ionic surfactant present in pesticide formulation as adjuvant and is known to contaminate food and drinking water. These chemicals may be affecting reproduction and sex differentiation of fish species [24,25]. Nhsitez pas nous laisser un commentaire ! The impacts of NP in the environment include feminization of aquatic organisms, decrease in male fertility, and the survival of juveniles at concentrations as low as 8.2g/L [81]. In vitro reporter gene assay revealed that relative potency of NP to estradiol-17 for medaka estrogen receptor is 0.5% [7]. 4dB~8QY^ $m 3xp# _ejmm1fj# Overexpression of cathepsin D induced by estrogen is frequently observed as a feature of metastatic breast cancer [91]. Javascript is currently disabled in your browser. ]]]U|cF!OW}~0P##[[m7@6nt@7&wz<5F}|||&`FP3%#AEvOo1pTe n^M?Hr(rbH}Td+J$cW=DUd8XkvJ_1rZ Web site owner: (A) Expression levels of TGF-R1 by treatment with E2, OP, or NP. B.G.J. x}|[ B#!, In addition to fetal exposure to 4-n-OP, neonatal exposure to 4-tert-OP also caused abnormal expression of ER and subsequent alteration of cell proliferating activity in the developing Donryu rat uterus [94]. PND 14, the second week of life, is coincident with the normal time for differentiation when the luminal epithelium invaginates into the stroma to form uterine glands. Nonylphenol derives from detergents. This question is for testing whether or not you are a human visitor and to prevent automated spam submissions. Read more, Coal tar pitch was included in Annex XIV of REACH on 14th June 2017. Chemicals/Toxicology Wash all contaminated surfaces with a soap and water solution. Its considered also an indirect additive used in food contact substances. ALPHA(NONYLPHENYL)-OMEGA-HYDROXYPOLY(OXY-1,2-ETHANEDIYL), ALPHA-(NONYLPHENYL)-OMEGA-HYDROXYPOLY(OXY-1,2-ETHANEDIYL), ALPHA-(NONYLPHENYL)-OMEGA-HYDROXYPOLYOXYETHYLENE, ETHANOL, 2-[2-[2-[2-(4-NONYLPHENOXY)ETHOXY]ETHOXY]ETHOXY]-, GLYCOLS, POLYETHYLENE, MONO(NONYLPHENYL) ETHER, 3,6,9,12,15,18,21-HEPTAOXATRICOSAN-1-OL, 23-(NONYLPHENOXY)-, 3,6,9,12,15,18,21,24,27-NONAOXANONACOSAN-1-OL, 29-(NONYLPHENOXY)-, 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, 26-(NONYLPHENOXY)-, OMEGA-HYDROXY-ALPHA-(NONYLPHENYL)POLY(OXY-1,2-ETHANEDIYL), POLY(OXY-1,2-ETHANEDIYL), ALPHA-(2-NONYLPHENYL)-OMEGA-HYDROXY-, POLY(OXY-1,2-ETHANEDIYL), ALPHA-(4-NONYLPHENYL)-OMEGA-HYDROXY-, POLY(OXY-1,2-ETHANEDIYL), ALPHA-(4-NONYLPHENYL)-OMEGA-HYDROXY-, BRANCHED, POLY(OXY-1,2-ETHANEDIYL), ALPHA-(ISONONYLPHENYL)-OMEGA-HYDROXY-, POLY(OXY-1,2-ETHANEDIYL), ALPHA-(NONYLPHENYL)-OMEGA-HYDROXY-, POLY(OXY-1,2-ETHANEDIYL), ALPHA-(NONYLPHENYL)-OMEGA-HYDROXY-, BRANCHED, POLY(OXY-1,2-ETHANEDIYL),ALPHA-(NONYLPHENYL)-OMEGA-HYDROXY, POLYETHYLENE GLYCOL 450 NONYL PHENYL ETHER, POLYETHYLENE GLYCOL MONO(NONYLPHENOL) ETHER, POLYETHYLENE GLYCOL MONO(NONYLPHENYL) ETHER, POLYETHYLENE GLYCOL NONYLPHENYL MONOETHER, POLYETHYLENE GLYCOLS MONO(NONYLPHENYL)ETHER, POLYETHYLENEOXIDE MONO(NONYLPHENYL) ETHER. The present study thus suggests that neonatal exposure to high doses of EDCs with estrogenic activity can induce abnormal differentiation in the developing rat uteri via abnormal ER expression and subsequent alteration of cell proliferating activity. APEs are also components of biocides, plastics, and paints. v\?6ucXL}@OB &@Iqe~eo9ycfJSmKi]bQpc/0 n^>24by0Y+ Nonylphenol ethoxylates are being replaced by other surfactants, mainly alcohol ethoxylates, in most European, Canadian, and Japanese markets. According to the data provided by U.S. Environmental Protection Agency NP and nonylphenol ethoxylates (NPEs) Action Plan ([RIN 2070-ZA09], /18/2010), general population exposure to NP has been confirmed by biomonitoring data from breast milk [77], umbilical cord blood [78], and urine [79]. NP has estrogenic activity by binding to estrogen receptors (ERs) in both in vitro and in vivo assay systems. Our experts carry out your Authorisation request and get the review periods you need. The substance entered Annex XIV of REACH for its endocrine disrupting properties. How are cosmetic color additives regulated in the U.S.? Colorless liquid or white solid with a mild odor. Whether the substance works with a threshold or not is not determined for these endocrine disruptors. The other three chemicals are currently under data analysis, and risk assessment of these chemicals will be conducted in the near future. May react exothermically with strong oxidizing agents. This pathway can modulate the expression of the DNA-methyltransferase-3 (Dnmt3) gene family which is involved in DNA methylation control, and hence, ER36-dependent control of the epigenetic status opens the way for the understanding of the link between endocrine disruptor exposure and the burden of hormone sensitive cancers [75]. For information relating to LGCs data processing activities, please visit our Privacy Policy below (see footer). 313% indicates that this is a member of the EPCRA section 313 Nonylphenol Ethoxylates category. Read more, Bis(2-methoxyethyl) phthalate was included in Annex XIV of REACH on 14th June 2017. We are passionate about supporting your science for a safer world. hiiS?$3BVhOV},`aFF {nSuT@6!C For 8 weeks, the mice were injected with corn oil, E2, OP, or TCS without ICI 182,780 (B) or with ICI 182,780 (C). Taisen Iguchi, Kunihiko Yamazaki, in Neuroendocrine Regulation of Animal Vocalization, 2021. If you accept without changing your settings, we assume that you are happy to receive all cookies on the LGC website. Copyright 2022 Elsevier B.V. or its licensors or contributors. Microbial breakdown of the latter results in the release of nonylphenol (Kennedy et al., 2013; Stasinakis and Gatidou, 2019). Shinichi Miyagawa, Taisen Iguchi, in Handbook of Hormones, 2016. 202, Cyber City, Tower-S4, Magarpatta City, Hadapsar PUNE Pune MH 411013. Please add to your cart and checkout as normal. ?jW(.#|>M]A{/j e~o,.FCd~Td;ZUsWTU5 y~}c6e0j:BK[PrX:qQ3?.*luvbO 4-Nonylphenol and REACH authorisation: what you must know, Tetramethylbutyl phenol, ethoxylated and REACH authorisation: what you must know, Coal tar pitch and REACH authorisation: what you must know, Bis(2-methoxyethyl) phthalate and REACH authorisation: what you must know. 1.4 [85]. EYES: First check the victim for contact lenses and remove if present. NP has greater binding affinity for fish ER than for human ER, and induces the formation of testisova (oocytes in the testis) of Japanese medaka at environmentally relevant concentrations [6]. And we do it for free. There is no information on whether NP is carcinogenic in laboratory animals or in humans. Receive the latest regulatory news and expert advice once a month. Authors highlighted the need for in-depth study of the isomer-specific toxicity, with the individual analysis of NPEO homologs and their degradation product NP isomers. NP's main use is in the manufacture of nonylphenol ethoxylates, which are nonionic surfactants. {{{aNBjJuV=M;?G>}wl* EXF VRk+AO31@&mnQ65l?8X_]OOzC% jHi~ Uo(kjjjlldl[0Y:8!Nb(o>?r Recently, it was demonstrated that NP accelerates growth of MCF-7 breast cancer cells by regulating the expression of cell cycle-related genes such as cyclin D1 and p21 and promotes cancer metastasis through amplification of cathepsin D, a lysosomal aspartyl protease involved in tumor metastasis, via ER signaling [90]. The exposure duration was short, the concentration of NP used was environmentally relevant, and the chemicals used (NP and E2) have low (or no) persistence in tissue. +{{cartData.totalItems - displayNumberOfProducts}} additional products, Enzyme activators, inhibitors & substrates, Standards for environmental regulatory methods, Process materials, geological, cement & soils, COVID-19 research and reference materials. Fire Extinguishing Agents Not to Be Used: Water may be ineffective on fire. Occurrence of nonylphenol in wastewater effluent from activated sludge plants (035gL1), as well as river water (3.0gL1) and groundwater (2.0gL1) has been documented for four decades (Commission of the European Communities, 1981). Software development, Headquarters: 195 Rue Jean-Jacques Rousseau, 92130 Issy-les-Moulineaux, Office: 34 Avenue des Champs-lyses, 75008 Paris, Subsidiary: EcoMundo, 503, 10th floor, Teheran-ro, Gangnam-gu, Seoul, South-Korea, Subsidiary: 4284 Rue de la Roche, Montreal, QC H2J 3H9, Subsidiary : 160 City Road, London, EC1V 2NX, Subsidiary: c/ Pallars, 193 Barcelona 08005, Subsidiary: Unit No. The action of 4-tert-OP via ER mediation was definitely proved by cotreatment of fulvestrant (ICI 182,780), a typical ER antagonist, as shown in Fig. More info about absorbents, including situations to watch out for National Oceanic and Atmospheric Administration, Ethoxylated nonylphenol; (Nonyl phenyl polyethylene glycol ether) (9016-45-9), Glycols, polyethylene, mono(p-nonylphenyl) ether (26027-38-3), Nonylphenoxypolyethoxyethanol (68412-54-4), Nonylphenol, 4-, branched, ethoxylated (127087-87-0), 3,6,9,12,15,18,21,24,27-Nonaoxanonacosan-1-ol, 29-(nonylphenoxy)-, 3,6,9,12,15,18,21,24-Octaoxahexacosan-1-ol, 26-(nonylphenoxy)-, 3,6,9,12,15,18,21-Heptaoxatricosan-1-ol, 23-(nonylphenoxy)-, Ethanol, 2-[2-[2-[2-(4-nonylphenoxy)ethoxy]ethoxy]ethoxy]-, Poly(oxy-1,2-ethanediyl), alpha-(2-nonylphenyl)-omega-hydroxy-, Poly(oxy-1,2-ethanediyl), alpha-(4-nonylphenyl)-omega-hydroxy-, Poly(oxy-1,2-ethanediyl), alpha-(4-nonylphenyl)-omega-hydroxy-, branched, Poly(oxy-1,2-ethanediyl), alpha-(isononylphenyl)-omega-hydroxy-, Poly(oxy-1,2-ethanediyl), alpha-(nonylphenyl)-omega-hydroxy-, Poly(oxy-1,2-ethanediyl), alpha-(nonylphenyl)-omega-hydroxy-, branched. Estrogenic effects of industrial chemicals such as bisphenol-A, Assessment strategies of endocrine disrupters under regulations of the Ministry of the Environment of Japan, Neuroendocrine Regulation of Animal Vocalization, MEOGRT of a Tier 2 test was applied to four chemicals, 4-, Endocrine disruptors in human milk and the health-related issues of breastfeeding, Bisphenol A (BPA), a primary monomer in polycarbonate plastic and epoxy resins, and. Chemicals having anti-thyroid hormone activity have also been reported, using amphibian metamorphosis assay [5,6]. Figure 7.5. Therefore, they appear to promote the development and progression of estrogen-dependent cancers [84]. Our experts give you key information on this substance, as well as advice to follow before going ahead. NP is shown to cause reproductive effects, in laboratory animals, that are thought to be linked to NP's estrogenic activity. USA.gov. The maximum level of NP found in the breast milk was 56.3g/L (3.0107M), leading to an estimated maximum dose for an infant of 3.9g/kg/day (2.0108mol/kg/day) [77]. reported that polystyrene tubes used in routine laboratory procedures released a substance with estrogenic properties and identified the substance as a nonylphenol. . If not, click 'cancel'. 4-tert-OP was also revealed to accelerate MCF-7 breast cancer growth in cellular and xenografted mouse model by regulating cell cycle-related genes through an ER-mediated pathway [92]. endobj Via expert services and software, we support the launch of industrial products, enabling companies to manage risks relating to chemical substances. What must you know before starting such application? After receiving your order confirmation, please contact us using the 'Contact us' form. However, if you would like to, you can change your cookie settings at anytime. APEs are surfactants that are used in domestic and industrial detergents such as de-resinating agents, wetting agents, and degreasers. : {{entry.product.biosafetyLevel == -1 ? Explore our reference standards supporting COVID-19 testing. The immunohistochemical investigation did not reveal any abnormalities in expression of the proto-oncogene c-fos, mitotic inhibitor p21, or EGF antigen, although the apoptotic index in the luminal epithelium was slightly increased in the OP-treated group. Triton or 4-Nonylphenol, branched and linear, ethoxylated, 4-Nonylphenol, branched and linear, ethoxylated [substances with a linear and/or branched alkyl chain with a carbon number of 9 covalently bound in position 4 to phenol, ethoxylated covering UVCB- and well-defined substances, polymers and homologues, which include any of the individual isomers and/or combinations thereof], Intrinsic property for which it was included in Annex XIV of REACH, Latest date to submit the authorisation dossier to ECHA. Regulations By continuing you agree to the use of cookies. Expression level of TGF-R1 and TGF-R2 was detected by using semiquantitative reverse-transcription PCR. We generate it for you in 5 minutes! Within the form, select the 'Exact weight order' as the nature of enquiry and include your order number within the detail box, Enter your email address and we'll email you the relevant CoA for lots: {{pdpCoaSelectedLotNumbers}}, We will be sending the CoA to your email address{{pdpCoaEmailPopupData.userEmail}}, 4-Nonylphenol-ethoxylate (penta-) (technical) (branched). This highlights the consequences of the timing of exposure, where exposures that occur during particularly sensitive stages of development can have implications long after the exposure has ceased. The European Commission specifies that if an applicant decides to take the risk management route, it will be the applicants responsibility to demonstrate the existence of. Lower Explosive Limit (LEL): data unavailable, Upper Explosive Limit (UEL): data unavailable, Autoignition Temperature: data unavailable, Vapor Density (Relative to Air): data unavailable, Ionization Energy/Potential: data unavailable. 4-nonylphenol is an estrogenic endocrine active chemical that is a derivative from ethoxylated alkylphenol, a non-ionic surfactant present in pesticide formulation as adjuvant and is known to contaminate food and drinking water. We use cookies to ensure that we give you the best experience of our website. Today, our portfolio is constantly expanding to adapt to changing regulations and technology, as we support your need for high-quality reference materials for food and environmental analysis. 17-Ethinylestradiol, synthesized for contraceptive pills and equilins used for hormone replacement therapy, have been found in river water in various countries, including the UK [5,6]. BG-1 cells were seeded in 6-well plates and treated with E2 (109M), OP (106M), or NP (106M). known to react with the Sumpter and Jobling suggested that NP contained in effluent from sewage treatment works is associated with vitellogenesis in male rainbow trout [5]. for 1+3, enter 4. It will be banned in Europe from At PND 28, ER expression in the luminal epithelium of the OP-treated group was decreased, in association with decline in the luminal epithelial areas. Furthermore, because of continuous discharge to wastewater, the substance is subject to pseudo-persistence effects. %PDF-1.4 Analysis of more samples is required to better understand the general contamination level of human milk. In an in vitro cellular model using BG-1 ovarian cancer cell line, 4-tert-OP and 4-NP promoted cell growth by inhibiting TGF- signaling via downregulation of TGF- R2, instead of TGF- R1, and upregulation of c-myc oncogene, which was mediated by upregulation of ER signaling pathway as seen in Fig.

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